# OnCo record irinotecan-early-cholinergic-syndrome-and-late-diarrhoea (protocol). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/protocols/irinotecan-early-cholinergic-syndrome-and-late-diarrhoea/>
  a schema:MedicalGuideline ;
  onco:kind "protocol" ;
  schema:identifier "irinotecan-early-cholinergic-syndrome-and-late-diarrhoea" ;
  schema:name "Irinotecan: early cholinergic syndrome and late diarrhoea"@en ;
  schema:alternateName "irinotecan cholinergic syndrome"@en, "atropine with irinotecan"@en, "irinotecan late diarrhoea"@en, "high-dose loperamide after irinotecan"@en, "sacituzumab govitecan diarrhoea"@en, "CPT-11 diarrhoea"@en ;
  schema:description "Irinotecan can cause two kinds of diarrhoea. The first comes during or soon after the drip, with sweating, watery eyes and cramps; an atropine injection stops it. The second starts a day or more later and can be serious: take 4 mg of loperamide at the first loose stool, then 2 mg every 2 hours, and call your team if it is not controlled in 24 hours, or with blood, fever or faintness."@en ;
  schema:url <https://onco.cc/protocols/irinotecan-early-cholinergic-syndrome-and-late-diarrhoea/> ;
  schema:dateModified "2026-11-11"^^xsd:date ;
  onco:tag "protocol", "diarrhoea", "supportive-care" ;
  onco:related <https://onco.cc/protocols/treatment-induced-diarrhoea-grading-and-management/>, <https://onco.cc/drugs/octreotide-lanreotide/>, <https://onco.cc/protocols/febrile-neutropenia-first-hour/> ;
  onco:sections <https://onco.cc/fronts/supportive-care/> ;
  onco:technologies <https://onco.cc/technologies/ugt1a1-genotyping/> ;
  onco:targets <https://onco.cc/targets/ugt1a1/> ;
  onco:drugs <https://onco.cc/drugs/irinotecan/>, <https://onco.cc/drugs/sacituzumab-govitecan/>, <https://onco.cc/drugs/folfiri/>, <https://onco.cc/drugs/folfoxiri/> ;
  onco:companies <https://onco.cc/companies/pfizer/> ;
  onco:institutions <https://onco.cc/institutions/nci/> ;
  onco:terms <https://onco.cc/terms/ctcae-grading/>, <https://onco.cc/terms/febrile-neutropenia/>, <https://onco.cc/terms/chemotherapy-side-effects-colorectal/>, <https://onco.cc/terms/chemotherapy-side-effects-pancreatic/> .