# OnCo record isotretinoin (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/isotretinoin/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "isotretinoin" ;
  schema:name "Isotretinoin"@en ;
  schema:alternateName "13-cis-retinoic acid"@en, "13-cis-RA"@en, "cis-retinoic acid"@en, "Accutane" ;
  schema:description "Isotretinoin, the acne drug, is given to children with high-risk neuroblastoma for six months after transplant to nudge any surviving cancer cells into growing up into harmless nerve cells. A 1999 trial showed it improved survival and it has been part of standard care since."@en ;
  schema:url <https://onco.cc/drugs/isotretinoin/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Isotretinoin> ;
  schema:citation <https://en.wikipedia.org/wiki/Isotretinoin> ;
  onco:status "approved" ;
  onco:tag "subtype-drugs-wave" ;
  onco:modality "Oral retinoid (differentiating agent)" ;
  onco:approval "US 1982: Severe recalcitrant nodular acne (use in high-risk neuroblastoma is off-label but standard)" ;
  onco:related <https://onco.cc/drugs/dinutuximab/>, <https://onco.cc/drugs/tretinoin-atra/> ;
  onco:cancers <https://onco.cc/cancers/neuroblastoma/>, <https://onco.cc/cancers/neuroblastoma-high-risk/>, <https://onco.cc/cancers/medulloblastoma-group-3-4/> ;
  onco:targets <https://onco.cc/targets/rara/>, <https://onco.cc/targets/rxr/> .