# OnCo record jak-stat (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/jak-stat/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "jak-stat" ;
  schema:name "JAK-STAT signalling"@en ;
  schema:description "The relay that turns cytokine signals into gene changes. Overactive in blood cancers (JAK2 in myelofibrosis), it is also the wire that carries interferon's cancer-killing message, so tumours cut it to escape immunotherapy."@en ;
  schema:url <https://onco.cc/pathways/jak-stat/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway> ;
  owl:sameAs <http://www.wikidata.org/entity/Q902835> ;
  schema:citation <https://doi.org/10.1038/s41392-021-00791-1> ;
  onco:tag "mechanism" ;
  onco:cancers <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:targets <https://onco.cc/targets/pdl1/>, <https://onco.cc/targets/stat5/>, <https://onco.cc/targets/mpl/>, <https://onco.cc/targets/jak1/> ;
  onco:institutions <https://onco.cc/institutions/mskcc/>, <https://onco.cc/institutions/mayo-clinic/> ;
  onco:pathways <https://onco.cc/pathways/antigen-presentation-immunoediting/>, <https://onco.cc/pathways/inflammation-nfkb/>, <https://onco.cc/pathways/cachexia-biology/>, <https://onco.cc/pathways/pd1-checkpoint/> ;
  onco:terms <https://onco.cc/terms/crs/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-darnell-jak-stat-science-1994/>, <https://onco.cc/key-papers/paper-hu-signal-transduct-target-ther/> .