# OnCo record jak1 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/jak1/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "jak1" ;
  schema:name "JAK1"@en ;
  schema:alternateName "Janus kinase 1"@en, "JAK1A"@en, "JTK3"@en, "JAK1" ;
  schema:description "JAK1 is one of the kinases that pass cytokine and interferon signals inside immune and blood cells. Ruxolitinib and momelotinib block JAK1 together with JAK2 to calm the inflammation of myelofibrosis; golidocitinib is the first JAK1-only inhibitor approved for a cancer, in peripheral T-cell lymphoma."@en ;
  schema:url <https://onco.cc/targets/jak1/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6190>, <https://www.uniprot.org/uniprotkb/P23458/entry>, <https://www.ncbi.nlm.nih.gov/gene/3716> ;
  onco:tag "wave5-target" ;
  onco:targetClass "kinase" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6190>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000162434>, <https://www.uniprot.org/uniprotkb/P23458/entry>, <https://www.ncbi.nlm.nih.gov/gene/3716> ;
  onco:related <https://onco.cc/drugs/pacritinib/>, <https://onco.cc/targets/jak2/> ;
  onco:cancers <https://onco.cc/cancers/myeloproliferative-neoplasms/>, <https://onco.cc/cancers/primary-myelofibrosis/>, <https://onco.cc/cancers/peripheral-t-cell-lymphoma/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:drugs <https://onco.cc/drugs/golidocitinib/>, <https://onco.cc/drugs/ruxolitinib/>, <https://onco.cc/drugs/momelotinib/> ;
  onco:pathways <https://onco.cc/pathways/jak-stat/>, <https://onco.cc/pathways/antigen-presentation-immunoediting/> .