# OnCo record jak2 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/jak2/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "jak2" ;
  schema:name "JAK2"@en ;
  schema:description "The signalling enzyme that tells marrow cells to make red cells and platelets; a single mutation (V617F) leaves it switched on in most myeloproliferative neoplasms."@en ;
  schema:url <https://onco.cc/targets/jak2/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Janus_kinase_2>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6192>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000096968>, <https://www.uniprot.org/uniprotkb/O60674/entry>, <https://www.ncbi.nlm.nih.gov/gene/3717> ;
  owl:sameAs <http://www.wikidata.org/entity/Q14914514> ;
  schema:citation <https://doi.org/10.1056/NEJMoa051113>, <https://doi.org/10.1038/ncomms7025>, <https://doi.org/10.1182/blood-2010-05-282780>, <https://doi.org/10.1200/JCO.2016.66.4482>, <https://doi.org/10.1038/nature09754>, <https://doi.org/10.1056/NEJMoa1411087> ;
  onco:tag "gap-fill" ;
  schema:alternateName "JAK2" ;
  onco:targetClass "kinase" ;
  onco:firstDescribed "1997"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/myeloproliferative-neoplasms/>, <https://onco.cc/cancers/all-leukemia/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:drugs <https://onco.cc/drugs/ruxolitinib/>, <https://onco.cc/drugs/fedratinib/>, <https://onco.cc/drugs/pacritinib/>, <https://onco.cc/drugs/momelotinib/>, <https://onco.cc/drugs/ropeginterferon-alfa-2b/> ;
  onco:pathways <https://onco.cc/pathways/pi3k-akt-mtor/>, <https://onco.cc/pathways/chemical-carcinogenesis-receptor-activation/>, <https://onco.cc/pathways/pancreatic-cancer-signalling/>, <https://onco.cc/pathways/jak-stat/>, <https://onco.cc/pathways/pd1-checkpoint/>, <https://onco.cc/pathways/antigen-presentation-immunoediting/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-kralovics-n-engl-j-med/> .