# OnCo record keap1-nrf2 (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/keap1-nrf2/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "keap1-nrf2" ;
  schema:name "KEAP1-NRF2 antioxidant pathway"@en ;
  schema:description "KEAP1-NRF2 is the cell's antioxidant defence switch. Lung cancers often break the off-switch (KEAP1), leaving NRF2 permanently on, which detoxifies chemotherapy and radiation and makes these tumours resistant to almost everything."@en ;
  schema:url <https://onco.cc/pathways/keap1-nrf2/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/NFE2L2> ;
  owl:sameAs <http://www.wikidata.org/entity/Q18030088> ;
  schema:citation <https://doi.org/10.1038/nm.4407> ;
  onco:tag "mechanism" ;
  onco:cancers <https://onco.cc/cancers/nsclc/> ;
  onco:targets <https://onco.cc/targets/kras/> ;
  onco:institutions <https://onco.cc/institutions/mskcc/>, <https://onco.cc/institutions/md-anderson/> ;
  onco:pathways <https://onco.cc/pathways/ferroptosis-cell-death/>, <https://onco.cc/pathways/cancer-metabolism/>, <https://onco.cc/pathways/ras-mapk/> ;
  onco:terms <https://onco.cc/terms/efflux-pump/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-romero-nat-med/> .