# OnCo record keap1 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/keap1/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "keap1" ;
  schema:name "KEAP1"@en ;
  schema:alternateName "kelch like ECH associated protein 1"@en, "Kelch-like ECH-associated protein 1"@en, "KIAA0132"@en, "MGC10630"@en, "MGC1114"@en, "MGC20887"@en, "MGC4407"@en, "MGC9454"@en, "INrf2"@en, "KLHL19"@en, "KEAP1" ;
  schema:description "KEAP1 (Kelch-like ECH-associated protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer, Hepatocellular carcinoma, Nasopharyngeal carcinoma and 3 more."@en ;
  schema:url <https://onco.cc/targets/keap1/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23177>, <https://www.uniprot.org/uniprotkb/Q14145/entry>, <https://www.ncbi.nlm.nih.gov/gene/9817>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000079999> ;
  onco:tag "cancer-genes-wave" ;
  onco:targetClass "tumor-suppressor" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23177>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000079999>, <https://www.uniprot.org/uniprotkb/Q14145/entry>, <https://www.ncbi.nlm.nih.gov/gene/9817> ;
  onco:related <https://onco.cc/collections/civic/>, <https://onco.cc/collections/open-targets/>, <https://onco.cc/collections/intogen/> ;
  onco:cancers <https://onco.cc/cancers/lung-cancer/>, <https://onco.cc/cancers/hcc/>, <https://onco.cc/cancers/nasopharyngeal/>, <https://onco.cc/cancers/neuroendocrine/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/cholangiocarcinoma/> ;
  onco:pathways <https://onco.cc/pathways/hepatocellular-carcinoma-signalling/>, <https://onco.cc/pathways/keap1-nrf2/> ;
  onco:trials <https://onco.cc/trials/nct05276726/>, <https://onco.cc/trials/nct06008093/> .