# OnCo record keynote-177 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/keynote-177/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "keynote-177", "NCT02563002" ;
  schema:name "KEYNOTE-177"@en ;
  schema:description "The trial that made immunotherapy alone, with no chemotherapy, the first treatment for the 5% of bowel cancers with a broken DNA spell-checker. Over half of patients were alive at five years."@en ;
  schema:url <https://onco.cc/trials/keynote-177/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT02563002>, <https://www.annalsofoncology.org/article/S0923-7534(24)04949-4/fulltext> ;
  onco:status "positive" ;
  onco:phase "3" ;
  schema:startDate "2015-11-30" ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/msi-high-colorectal/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:targets <https://onco.cc/targets/pd1/> ;
  onco:drugs <https://onco.cc/drugs/pembrolizumab/> ;
  onco:companies <https://onco.cc/companies/merck/> ;
  onco:terms <https://onco.cc/terms/msi/> ;
  onco:trials <https://onco.cc/trials/calgb-80405/> ;
  onco:people <https://onco.cc/people/thierry-andre/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-le-mmr-deficiency-pd1-nejm-2015/>, <https://onco.cc/key-papers/paper-venderbosch-mmr-braf-metastatic-colorectal-pooled-ccr-2014/>, <https://onco.cc/key-papers/paper-keynote-177-nejm-2020/>, <https://onco.cc/key-papers/paper-keynote-177-lancet-oncol-2022-update/> .