# OnCo record keynote-522 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/keynote-522/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "keynote-522", "NCT03036488" ;
  schema:name "KEYNOTE-522"@en ;
  schema:description "The trial that added immunotherapy to pre-surgery chemotherapy for triple-negative breast cancer and, uniquely, improved survival."@en ;
  schema:url <https://onco.cc/trials/keynote-522/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT03036488>, <https://doi.org/10.1056/NEJMoa1910549>, <https://doi.org/10.1056/NEJMoa2112651>, <https://doi.org/10.1056/NEJMoa2409932>, <https://doi.org/10.1016/j.annonc.2024.02.002>, <https://www.nice.org.uk/guidance/ta851> ;
  onco:status "positive" ;
  onco:phase "3" ;
  schema:startDate "2017-03-07" ;
  onco:cancers <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/tnbc-early/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:drugs <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/carboplatin/>, <https://onco.cc/drugs/paclitaxel/> ;
  onco:companies <https://onco.cc/companies/merck/> ;
  onco:terms <https://onco.cc/terms/pcr/>, <https://onco.cc/terms/efs/>, <https://onco.cc/terms/rcb/>, <https://onco.cc/terms/tnbc-residual-disease-decision/> ;
  onco:trials <https://onco.cc/trials/swog-s1418/>, <https://onco.cc/trials/optimice-pcr/>, <https://onco.cc/trials/scarlet-s2212/>, <https://onco.cc/trials/ascent-05/>, <https://onco.cc/trials/tropion-breast03/> ;
  onco:people <https://onco.cc/people/rebecca-dent/>, <https://onco.cc/people/peter-schmid/>, <https://onco.cc/people/loi-sherene/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-keynote-522-n-engl-j-med-2020/>, <https://onco.cc/key-papers/paper-keynote-522-n-engl-j-med-2024-update/> .