# OnCo record kit-d816v (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/kit-d816v/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "kit-d816v" ;
  schema:name "KIT D816V"@en ;
  schema:alternateName "KIT D816V"@en, "D816V"@en, "c-KIT D816V"@en, "KIT exon 17 mutation"@en, "KIT D816V mastocytosis"@en ;
  schema:description "KIT D816V is the mutation behind almost every case of systemic mastocytosis. It makes the disease resistant to imatinib, and it is detected by a highly sensitive blood PCR; avapritinib treats the disease whether or not the mutation is confirmed."@en ;
  schema:url <https://onco.cc/biomarkers/kit-d816v/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=645c887c-8cd4-4623-8da9-ac223d71a8b9>, <https://www.fda.gov/medical-devices/in-vitro-diagnostics/list-cleared-or-approved-companion-diagnostic-devices-in-vitro-and-imaging-tools> ;
  onco:tag "biomarker", "kit" ;
  onco:related <https://onco.cc/biomarkers/pdgfra-exon-18-d842v/> ;
  onco:cancers <https://onco.cc/cancers/systemic-mastocytosis/>, <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/gist/> ;
  onco:drugs <https://onco.cc/drugs/imatinib/>, <https://onco.cc/drugs/avapritinib/> ;
  onco:terms <https://onco.cc/terms/gatekeeper-mutation/> .