# OnCo record kras-allelic-imbalance (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/kras-allelic-imbalance/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "kras-allelic-imbalance" ;
  schema:name "KRAS allelic imbalance and mutant KRAS dosage in pancreatic cancer"@en ;
  schema:alternateName "KRAS allelic imbalance"@en, "Mutant KRAS dosage"@en, "Loss of wild-type KRAS"@en, "KRAS major imbalance"@en, "KRAS copy gain"@en ;
  schema:description "Beyond which KRAS mutation a pancreatic tumour carries, how many copies of the mutant allele it has matters: tumours that lose the normal copy or gain extra mutant copies behave more aggressively and lean towards the basal-like subtype, which is one reason two tumours with the same KRAS mutation can look and behave differently."@en ;
  schema:url <https://onco.cc/terms/kras-allelic-imbalance/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/s41588-019-0566-9>, <https://doi.org/10.1038/nature19823> ;
  onco:tag "pancreatic-molecular" ;
  onco:related <https://onco.cc/biomarkers/kras-g12d/> ;
  onco:cancers <https://onco.cc/cancers/pancreatic/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/> ;
  onco:targets <https://onco.cc/targets/kras/> ;
  onco:terms <https://onco.cc/terms/kras-mutation-subtypes/>, <https://onco.cc/terms/classical-vs-basal-like/>, <https://onco.cc/terms/copy-number-variation-term/>, <https://onco.cc/terms/whole-genome-doubling/>, <https://onco.cc/terms/gata6-classical-basal-marker/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-chan-seng-yue-pancreatic-transcription-phenotypes-nat-genet-2020/>, <https://onco.cc/key-papers/paper-notta-punctuated-evolution-pancreatic-nature-2016/> .