# OnCo record kras-plus-egfr-crc (pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pairings/kras-plus-egfr-crc/>
  a schema:MedicalTherapy ;
  onco:kind "pairing" ;
  schema:identifier "kras-plus-egfr-crc" ;
  schema:name "KRAS G12C inhibitor + anti-EGFR antibody (colorectal)"@en ;
  schema:description "In colorectal cancer, a KRAS blocker alone has little effect because the cell turns EGFR up; adding an EGFR antibody stops that."@en ;
  schema:url <https://onco.cc/pairings/kras-plus-egfr-crc/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT05198934> ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:drugs <https://onco.cc/drugs/sotorasib/>, <https://onco.cc/drugs/adagrasib/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:trials <https://onco.cc/trials/codebreak-300/> ;
  onco:pairs <https://onco.cc/technologies/kras-inhibitors/>, <https://onco.cc/targets/egfr/> .