# OnCo record kristine (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/kristine/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "kristine", "NCT02131064" ;
  schema:name "KRISTINE"@en ;
  schema:description "KRISTINE tested whether an antibody-drug conjugate could replace chemotherapy before surgery in HER2-positive breast cancer and found it could not: fewer tumours disappeared and more grew before the operation."@en ;
  schema:url <https://onco.cc/trials/kristine/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT02131064>, <https://doi.org/10.1016/S1470-2045(17)30716-7> ;
  onco:status "negative" ;
  onco:tag "failure", "lesson:selection" ;
  onco:phase "3" ;
  onco:cancers <https://onco.cc/cancers/breast-her2-positive/>, <https://onco.cc/cancers/her2-positive-early-breast-cancer/> ;
  onco:targets <https://onco.cc/targets/her2/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab-emtansine/>, <https://onco.cc/drugs/pertuzumab/>, <https://onco.cc/drugs/docetaxel/>, <https://onco.cc/drugs/carboplatin/>, <https://onco.cc/drugs/trastuzumab/> ;
  onco:terms <https://onco.cc/terms/pcr/> ;
  onco:people <https://onco.cc/people/sara-hurvitz/> .