# OnCo record li-fraumeni (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/li-fraumeni/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "li-fraumeni" ;
  schema:name "Li-Fraumeni syndrome (germline TP53)"@en ;
  schema:description "Li-Fraumeni syndrome is an inherited fault in the TP53 gene giving a lifetime cancer risk near 100% in women and ~75% in men, with sarcomas, breast cancer, brain tumours, adrenal cancer and leukaemias often in childhood. Whole-body MRI surveillance saves lives."@en ;
  schema:url <https://onco.cc/terms/li-fraumeni/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Li–Fraumeni_syndrome> ;
  schema:citation <https://doi.org/10.1016/S1470-2045(16)30249-2>, <https://www.lfsassociation.org/> ;
  onco:tag "gap-fill", "hereditary" ;
  onco:related <https://onco.cc/targets/tp53/>, <https://onco.cc/terms/hereditary-cancer-syndromes/>, <https://onco.cc/technologies/whole-body-mri/>, <https://onco.cc/cancers/adrenocortical/>, <https://onco.cc/cancers/osteosarcoma/>, <https://onco.cc/cancers/rhabdomyosarcoma/>, <https://onco.cc/cancers/medulloblastoma/>, <https://onco.cc/cancers/sarcoma/> ;
  onco:terms <https://onco.cc/terms/germline-vs-somatic/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-villani-lancet-oncol/> .