# OnCo record lipid-metabolism-cancer (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/lipid-metabolism-cancer/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "lipid-metabolism-cancer" ;
  schema:name "Lipid synthesis, uptake & cholesterol"@en ;
  schema:description "Dividing cells need membranes, and membranes are fat. Cancers switch on the fat-building enzymes most adult tissues keep off, and in fatty environments (breast, omentum, bone marrow) they also steal lipids from neighbouring fat cells. This links obesity to cancer and offers new drug targets."@en ;
  schema:url <https://onco.cc/pathways/lipid-metabolism-cancer/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Fatty_acid_synthesis> ;
  schema:citation <https://doi.org/10.1038/nrc.2016.89> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:cancers <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/endometrial/>, <https://onco.cc/cancers/hcc/> ;
  onco:technologies <https://onco.cc/technologies/metabolic-therapy/>, <https://onco.cc/technologies/glp1-agonists-cancer-risk/>, <https://onco.cc/technologies/bariatric-surgery-cancer-incidence/>, <https://onco.cc/technologies/mediterranean-plant-forward-diet/>, <https://onco.cc/technologies/exercise-oncology/>, <https://onco.cc/technologies/dietitian-led-weight-loss-breast/> ;
  onco:targets <https://onco.cc/targets/akt/>, <https://onco.cc/targets/kras/>, <https://onco.cc/targets/estrogen-receptor/> ;
  onco:pathways <https://onco.cc/pathways/cancer-metabolism/>, <https://onco.cc/pathways/ferroptosis-cell-death/>, <https://onco.cc/pathways/pi3k-akt-mtor/>, <https://onco.cc/pathways/tumor-dormancy/> ;
  onco:terms <https://onco.cc/terms/obesity-related-cancers/>, <https://onco.cc/terms/energy-balance/>, <https://onco.cc/terms/metabolic-syndrome/>, <https://onco.cc/terms/body-composition/>, <https://onco.cc/terms/deregulating-cellular-energetics/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-rohrig-nat-rev-cancer/> .