# OnCo record liv1 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/liv1/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "liv1" ;
  schema:name "LIV-1 (SLC39A6)"@en ;
  schema:description "LIV-1 is an oestrogen-regulated zinc transporter on most breast cancers; the ADC against it (ladiratuzumab vedotin) showed activity in triple-negative disease but was discontinued in 2024."@en ;
  schema:url <https://onco.cc/targets/liv1/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/SLC39A6>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18607>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000141424>, <https://www.uniprot.org/uniprotkb/Q13433/entry>, <https://www.ncbi.nlm.nih.gov/gene/25800> ;
  schema:citation <https://doi.org/10.1200/JCO.2019.37.15_suppl.1094> ;
  onco:tag "gap-fill", "discontinued" ;
  schema:alternateName "SLC39A6" ;
  onco:targetClass "surface-antigen" ;
  onco:firstDescribed "2001"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/prostate/> ;
  onco:technologies <https://onco.cc/technologies/adc/> ;
  onco:companies <https://onco.cc/companies/pfizer/> .