# OnCo record lurbinectedin (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/lurbinectedin/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "lurbinectedin" ;
  schema:name "Lurbinectedin"@en ;
  schema:description "A marine-derived chemotherapy that jams cancer's gene-reading machinery, approved for relapsed small-cell lung cancer and, since 2025, as first-line maintenance with atezolizumab."@en ;
  schema:url <https://onco.cc/drugs/lurbinectedin/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Lurbinectedin> ;
  owl:sameAs <http://www.wikidata.org/entity/Q27254568> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Lurbinectedin> ;
  onco:status "approved" ;
  onco:modality "Cytotoxic (transcription inhibitor)" ;
  schema:alternateName "Zepzelca" ;
  onco:approval "US 2020: Metastatic SCLC after platinum chemotherapy (accelerated)", "US 2025: First-line maintenance with atezolizumab in ES-SCLC (full approval)", "EU 2026: Maintenance with atezolizumab in ES-SCLC after first-line induction; 29 May 2026" ;
  onco:acceleratedApproval "US 2020-06-15: Treatment of adult patients with metastatic small cell lung cancer (SCLC) with disease progression on or after prior platinum-based chemotherapy ." ;
  onco:cancers <https://onco.cc/cancers/sclc/>, <https://onco.cc/cancers/extensive-stage-sclc/>, <https://onco.cc/cancers/lung-cancer/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/> ;
  onco:companies <https://onco.cc/companies/jazz/>, <https://onco.cc/companies/pharmamar/> ;
  onco:trials <https://onco.cc/trials/imforte/>, <https://onco.cc/trials/atlantis/>, <https://onco.cc/trials/nct07625644/>, <https://onco.cc/trials/nct06801834/>, <https://onco.cc/trials/nct06496048/>, <https://onco.cc/trials/nct05652686/>, <https://onco.cc/trials/nct05734066/>, <https://onco.cc/trials/nct07155174/>, <https://onco.cc/trials/nct07459634/>, <https://onco.cc/trials/nct06088290/>, <https://onco.cc/trials/lurbinectedin-basket-sclc/> .