# OnCo record lymphodepletion (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/lymphodepletion/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "lymphodepletion" ;
  schema:name "Lymphodepletion before CAR-T"@en ;
  schema:alternateName "lymphodepleting"@en, "lymphodepleting chemotherapy"@en, "lymphodepletion chemotherapy"@en, "LD chemo"@en, "Flu/Cy"@en, "fludarabine/cyclophosphamide"@en, "fludarabine-cyclophosphamide"@en, "bendamustine lymphodepletion"@en, "making room"@en, "homeostatic expansion"@en ;
  schema:description "A short course of chemotherapy (usually fludarabine and cyclophosphamide) given in the days before a CAR-T infusion to clear out the patient's own lymphocytes, making room and growth signals for the engineered cells to expand."@en ;
  schema:url <https://onco.cc/terms/lymphodepletion/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Chimeric_antigen_receptor_T_cell> ;
  schema:citation <https://en.wikipedia.org/wiki/Chimeric_antigen_receptor_T_cell> ;
  onco:related <https://onco.cc/terms/conditioning-regimen/>, <https://onco.cc/terms/vein-to-vein-time/>, <https://onco.cc/terms/cytopenias/>, <https://onco.cc/terms/apheresis/> ;
  onco:sections <https://onco.cc/fronts/cell-therapy/> ;
  onco:technologies <https://onco.cc/technologies/car-t/>, <https://onco.cc/technologies/in-vivo-car-t/> ;
  onco:drugs <https://onco.cc/drugs/cyclophosphamide/>, <https://onco.cc/drugs/bendamustine/> .