# OnCo record lymphoma-bio-cell-of-origin-in-practice (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/lymphoma-bio-cell-of-origin-in-practice/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "lymphoma-bio-cell-of-origin-in-practice" ;
  schema:name "Cell of origin in practice: Hans against expression profiling, and what it changes"@en ;
  schema:alternateName "Hans algorithm"@en, "GCB versus non-GCB"@en, "Lymph2Cx"@en, "Cell of origin assay"@en ;
  schema:description "Large B-cell lymphoma is split into two types by which normal B cell it most resembles. The split is real and predicts how the disease behaves, but the test most laboratories run is a cheaper approximation of the one that defined it, and today the result rarely changes which treatment is given."@en ;
  schema:url <https://onco.cc/terms/lymphoma-bio-cell-of-origin-in-practice/> ;
  schema:dateModified "2026-09-30"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/35000501>, <https://doi.org/10.1056/NEJMoa012914>, <https://doi.org/10.1182/blood-2003-05-1545> ;
  onco:cancers <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/primary-cns-lymphoma/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:technologies <https://onco.cc/technologies/histopathology-ihc/>, <https://onco.cc/technologies/rna-seq/> ;
  onco:targets <https://onco.cc/targets/bcl2/>, <https://onco.cc/targets/bcl6/>, <https://onco.cc/targets/ezh2/>, <https://onco.cc/targets/cd79b/>, <https://onco.cc/targets/myd88/> ;
  onco:pathways <https://onco.cc/pathways/bcr-signalling/>, <https://onco.cc/pathways/germinal-centre-reaction/> ;
  onco:terms <https://onco.cc/terms/cell-of-origin/>, <https://onco.cc/terms/ihc/>, <https://onco.cc/terms/lymphoma-bio-lymphgen/> .