# OnCo record lymphoma-bio-germinal-centre (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/lymphoma-bio-germinal-centre/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "lymphoma-bio-germinal-centre" ;
  schema:name "The germinal centre: why lymphoma starts where antibodies are made"@en ;
  schema:alternateName "Germinal centre reaction"@en, "Somatic hypermutation"@en, "Class switch recombination"@en, "Affinity maturation"@en ;
  schema:description "To make a better antibody, a B cell has to deliberately damage its own DNA while dividing fast, with its safety checks switched off. Most B-cell lymphomas are cells that went into that process and never came out of it properly."@en ;
  schema:url <https://onco.cc/terms/lymphoma-bio-germinal-centre/> ;
  schema:dateModified "2026-09-30"^^xsd:date ;
  schema:citation <https://doi.org/10.1126/science.3929382>, <https://doi.org/10.1038/nature09730>, <https://doi.org/10.1038/ng.518> ;
  onco:cancers <https://onco.cc/cancers/non-hodgkin-lymphoma/>, <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/follicular-lymphoma/>, <https://onco.cc/cancers/burkitt-lymphoma/> ;
  onco:targets <https://onco.cc/targets/bcl6/>, <https://onco.cc/targets/ezh2/>, <https://onco.cc/targets/crebbp/>, <https://onco.cc/targets/ep300/>, <https://onco.cc/targets/bcl2/>, <https://onco.cc/targets/myc-gene/> ;
  onco:pathways <https://onco.cc/pathways/germinal-centre-reaction/>, <https://onco.cc/pathways/epigenetic-reprogramming/> ;
  onco:terms <https://onco.cc/terms/cell-of-origin/>, <https://onco.cc/terms/cytogenetics/>, <https://onco.cc/terms/gene-fusion/>, <https://onco.cc/terms/driver-mutation/> .