# OnCo record lymphoma-bio-lineage-antigen-cost (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/lymphoma-bio-lineage-antigen-cost/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "lymphoma-bio-lineage-antigen-cost" ;
  schema:name "What it costs to aim at a lineage antigen"@en ;
  schema:alternateName "Lineage antigen"@en, "On-target off-tumour toxicity"@en, "B-cell aplasia"@en, "Hypogammaglobulinaemia"@en ;
  schema:description "Almost every lymphoma drug that finds the cancer by a surface marker finds healthy cells carrying the same marker. The side effects are not accidents; they are the treatment working on the wrong cells, and they are predictable from the marker."@en ;
  schema:url <https://onco.cc/terms/lymphoma-bio-lineage-antigen-cost/> ;
  schema:dateModified "2026-09-30"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1807315>, <https://doi.org/10.1016/S1470-2045(18)30379-6> ;
  onco:cancers <https://onco.cc/cancers/non-hodgkin-lymphoma/>, <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/cutaneous-t-cell-lymphoma/>, <https://onco.cc/cancers/sezary-syndrome/>, <https://onco.cc/cancers/peripheral-t-cell-lymphoma/> ;
  onco:technologies <https://onco.cc/technologies/monoclonal-antibody/>, <https://onco.cc/technologies/car-t/>, <https://onco.cc/technologies/bispecific-antibody/>, <https://onco.cc/technologies/t-cell-engager/> ;
  onco:targets <https://onco.cc/targets/cd20/>, <https://onco.cc/targets/cd19/>, <https://onco.cc/targets/cd52/>, <https://onco.cc/targets/ccr4/>, <https://onco.cc/targets/cd47/>, <https://onco.cc/targets/cd38/>, <https://onco.cc/targets/cd3/>, <https://onco.cc/targets/cd22/>, <https://onco.cc/targets/cd79b/> ;
  onco:pathways <https://onco.cc/pathways/cd47-sirpa/> ;
  onco:terms <https://onco.cc/terms/lymphoma-bio-antigen-escape/>, <https://onco.cc/terms/lymphoma-tx-crs-icans/>, <https://onco.cc/terms/lymphoma-tx-immunoglobulin-replacement/>, <https://onco.cc/terms/lymphoma-tx-hepatitis-b-reactivation/> .