# OnCo record lymphoma-bio-transformation (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/lymphoma-bio-transformation/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "lymphoma-bio-transformation" ;
  schema:name "Transformation: when a slow lymphoma turns into a fast one"@en ;
  schema:alternateName "Histological transformation"@en, "Transformed follicular lymphoma"@en, "Richter transformation"@en, "Richter syndrome"@en ;
  schema:description "An indolent lymphoma can change into an aggressive one, usually by acquiring new genetic faults in the same clone. It is the commonest reason a person who has been well for years becomes unwell quickly, and it is treated as the aggressive disease rather than the original one."@en ;
  schema:url <https://onco.cc/terms/lymphoma-bio-transformation/> ;
  schema:dateModified "2026-09-30"^^xsd:date ;
  schema:citation <https://doi.org/10.1182/blood-2010-09-302174>, <https://doi.org/10.1182/blood-2012-06-435842> ;
  onco:cancers <https://onco.cc/cancers/follicular-lymphoma/>, <https://onco.cc/cancers/richter-transformation-cll/>, <https://onco.cc/cancers/marginal-zone-lymphoma/>, <https://onco.cc/cancers/waldenstrom/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:technologies <https://onco.cc/technologies/fdg-pet/>, <https://onco.cc/technologies/cytogenetics-fish/> ;
  onco:targets <https://onco.cc/targets/myc-gene/>, <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/cdkn2a/> ;
  onco:pathways <https://onco.cc/pathways/clonal-evolution/>, <https://onco.cc/pathways/p53-mdm2-axis/> ;
  onco:terms <https://onco.cc/terms/flipi/>, <https://onco.cc/terms/lymphoma-tx-pod24/>, <https://onco.cc/terms/deauville/> .