# OnCo record lymphoma-ev-genetic-subtype-directed-first-line (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/lymphoma-ev-genetic-subtype-directed-first-line/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "lymphoma-ev-genetic-subtype-directed-first-line" ;
  schema:name "Assign first-line treatment in diffuse large B-cell lymphoma by genetic subtype, not by a three-antibody stain"@en ;
  schema:alternateName "LymphGen-directed first-line therapy"@en, "Genetic subtype-directed treatment in diffuse large B-cell lymphoma"@en ;
  schema:description "Three genetic classifications of the commonest aggressive lymphoma exist and none of them yet decides anyone's treatment. The trial that would change that has not been run."@en ;
  schema:url <https://onco.cc/ideas/lymphoma-ev-genetic-subtype-directed-first-line/> ;
  schema:dateModified "2026-10-01"^^xsd:date ;
  onco:tag "lymphoma-evidence" ;
  onco:related <https://onco.cc/roadmaps/lymphoma-roadmap/> ;
  onco:cancers <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:sections <https://onco.cc/fronts/diagnostics/>, <https://onco.cc/fronts/targeted-therapy/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/terms/ngs/> ;
  onco:targets <https://onco.cc/targets/myd88/>, <https://onco.cc/targets/cd79b/>, <https://onco.cc/targets/bcl2/>, <https://onco.cc/targets/btk/>, <https://onco.cc/targets/ezh2/> ;
  onco:terms <https://onco.cc/terms/cell-of-origin/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-biomarker-validation/>, <https://onco.cc/bottlenecks/b-trial-design/>, <https://onco.cc/bottlenecks/b-translational-valley/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-wright-lymphgen-genetic-subtypes-dlbcl-cancer-cell-2020/>, <https://onco.cc/key-papers/paper-schmitz-genetics-pathogenesis-dlbcl-nejm-2018/>, <https://onco.cc/key-papers/paper-chapuy-molecular-subtypes-dlbcl-nat-med-2018/>, <https://onco.cc/key-papers/paper-phoenix-ibrutinib-r-chop-non-gcb-dlbcl-jco-2019/> .