# OnCo record lymphoma-tx-cns-prophylaxis (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/lymphoma-tx-cns-prophylaxis/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "lymphoma-tx-cns-prophylaxis" ;
  schema:name "CNS prophylaxis in aggressive B-cell lymphoma, and the evidence against it"@en ;
  schema:alternateName "Central nervous system prophylaxis"@en, "CNS-IPI"@en, "Intrathecal methotrexate prophylaxis"@en, "High-dose methotrexate prophylaxis"@en ;
  schema:description "Some people with aggressive lymphoma are given extra methotrexate, into the spine or into a vein, to stop the lymphoma reaching the brain. It has been standard for decades, and the best evidence now available suggests it does not work."@en ;
  schema:url <https://onco.cc/terms/lymphoma-tx-cns-prophylaxis/> ;
  schema:dateModified "2026-09-29"^^xsd:date ;
  schema:citation <https://doi.org/10.1200/JCO.2015.65.6520>, <https://doi.org/10.1182/blood.2021012888> ;
  onco:cancers <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/>, <https://onco.cc/cancers/burkitt-lymphoma/>, <https://onco.cc/cancers/primary-cns-lymphoma/> ;
  onco:drugs <https://onco.cc/drugs/methotrexate/>, <https://onco.cc/drugs/cytarabine/> ;
  onco:terms <https://onco.cc/terms/ipi-score/>, <https://onco.cc/terms/double-hit-lymphoma/>, <https://onco.cc/terms/intrathecal-therapy/>, <https://onco.cc/terms/cns-penetration/>, <https://onco.cc/terms/r-chop/> .