# OnCo record mdm2 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/mdm2/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "mdm2" ;
  schema:name "MDM2"@en ;
  schema:description "MDM2 is the protein that degrades p53; blocking it reactivates p53 in tumours where the gene is intact, especially the liposarcomas that carry extra copies of MDM2."@en ;
  schema:url <https://onco.cc/targets/mdm2/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Mdm2>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6973>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000135679>, <https://www.uniprot.org/uniprotkb/Q00987/entry>, <https://www.ncbi.nlm.nih.gov/gene/4193> ;
  owl:sameAs <http://www.wikidata.org/entity/Q18028978> ;
  schema:citation <https://doi.org/10.1038/ng.619> ;
  onco:tag "gap-fill" ;
  schema:alternateName "MDM2" ;
  onco:targetClass "other" ;
  onco:firstDescribed "1992"^^xsd:gYear ;
  onco:related <https://onco.cc/targets/tp53/> ;
  onco:cancers <https://onco.cc/cancers/sarcoma/>, <https://onco.cc/cancers/glioblastoma/>, <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/myeloproliferative-neoplasms/>, <https://onco.cc/cancers/gallbladder/> ;
  onco:technologies <https://onco.cc/technologies/protac-degrader/>, <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:drugs <https://onco.cc/drugs/krt-232/> ;
  onco:companies <https://onco.cc/companies/boehringer-ingelheim/> ;
  onco:pathways <https://onco.cc/pathways/p53-cell-cycle/>, <https://onco.cc/pathways/bladder-cancer-signalling/>, <https://onco.cc/pathways/glioma-signalling/>, <https://onco.cc/pathways/melanoma-signalling/>, <https://onco.cc/pathways/prostate-cancer-signalling/> ;
  onco:trials <https://onco.cc/trials/nct06578624/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-cowzer-biliary-targeted-therapy-determinants-ccr-2026/>, <https://onco.cc/key-papers/paper-barretina-nat-genet/> .