# OnCo record mechanical-theory-of-cancer (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/mechanical-theory-of-cancer/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "mechanical-theory-of-cancer" ;
  schema:name "Mechanical theory: stiffness, pressure and force as causes"@en ;
  schema:alternateName "mechanobiology of cancer"@en, "tensional homeostasis"@en, "physical oncology"@en, "solid stress hypothesis"@en, "matrix stiffness theory"@en, "mechanotransduction in cancer"@en ;
  schema:description "Cancer cells feel their surroundings. A stiff, dense matrix or a compressed tissue is not just a symptom but a signal that pushes cells towards malignancy, and pressure inside tumours squeezes vessels shut so drugs and oxygen cannot get in. Bissell and Weaver reverted cancer cells to normal by blocking the matrix; Rakesh Jain made solid stress and vessel normalisation a treatment strategy."@en ;
  schema:url <https://onco.cc/terms/mechanical-theory-of-cancer/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Mechanobiology> ;
  schema:citation <https://doi.org/10.1016/j.ccr.2005.08.010>, <https://doi.org/10.1016/j.cell.2009.10.027>, <https://doi.org/10.1126/science.aaz0868>, <https://doi.org/10.1016/j.ccell.2014.10.006>, <https://doi.org/10.1083/jcb.137.1.231>, <https://doi.org/10.1001/jamaoncol.2019.0892>, <https://doi.org/10.1200/JCO.20.00590> ;
  onco:tag "theory" ;
  onco:related <https://onco.cc/pathways/theories-of-cancer/>, <https://onco.cc/terms/tissue-organisation-field-theory/>, <https://onco.cc/terms/microenvironment-inflammation-theory/>, <https://onco.cc/terms/bioelectric-theory-of-cancer/>, <https://onco.cc/pathways/caf-activation-desmoplasia/>, <https://onco.cc/technologies/tumour-mechanics-models/>, <https://onco.cc/pathways/hippo-yap/>, <https://onco.cc/pathways/invasion-ecm-degradation/>, <https://onco.cc/pathways/basement-membrane-tissue-barriers/>, <https://onco.cc/pathways/vegf-angiogenesis/>, <https://onco.cc/terms/cancer-associated-fibroblasts/>, <https://onco.cc/terms/cirrhosis/>, <https://onco.cc/technologies/mathematical-oncology/> ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/breast-cancer/>, <https://onco.cc/cancers/hcc/> ;
  onco:technologies <https://onco.cc/technologies/tumour-mechanics-models/> ;
  onco:targets <https://onco.cc/targets/fap/>, <https://onco.cc/targets/vegf/> ;
  onco:drugs <https://onco.cc/drugs/bevacizumab/> ;
  onco:pathways <https://onco.cc/pathways/caf-activation-desmoplasia/>, <https://onco.cc/pathways/hippo-yap/>, <https://onco.cc/pathways/invasion-ecm-degradation/>, <https://onco.cc/pathways/basement-membrane-tissue-barriers/>, <https://onco.cc/pathways/vegf-angiogenesis/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-weaver-j-cell-biol/>, <https://onco.cc/key-papers/paper-halo-301-pegvorhyaluronidase-jco-2020/>, <https://onco.cc/key-papers/paper-murphy-jama-oncol/>, <https://onco.cc/key-papers/paper-jain-cancer-cell/>, <https://onco.cc/key-papers/paper-paszek-cancer-cell/>, <https://onco.cc/key-papers/paper-levental-cell/>, <https://onco.cc/key-papers/paper-nia-science/> .