# OnCo record mechlorethamine (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/mechlorethamine/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "mechlorethamine" ;
  schema:name "Mechlorethamine (chlormethine)"@en ;
  schema:alternateName "Nitrogen mustard"@en, "Chlormethine"@en, "Ledaga"@en, "Mustargen (historic) / Valchlor gel" ;
  schema:description "Mechlorethamine, or nitrogen mustard, was the first chemotherapy ever used, in 1940s Hodgkin lymphoma. Today its main use is as a skin gel (Valchlor in the US, Ledaga in Europe) for early cutaneous T-cell lymphoma."@en ;
  schema:url <https://onco.cc/drugs/mechlorethamine/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Chlormethine> ;
  schema:citation <https://doi.org/10.1001/2013.jamadermatol.541>, <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6a52e4c2-6a9f-4ebb-bc77-046b4f8bcd57>, <https://www.cancer.gov/about-cancer/treatment/drugs/mechlorethaminehydrochloride>, <https://www.ema.europa.eu/en/medicines/human/EPAR/ledaga> ;
  onco:status "approved" ;
  onco:tag "nci-list", "historic" ;
  onco:modality "Alkylating agent (nitrogen mustard); intravenous and topical gel" ;
  onco:approval "US 1949: Hodgkin disease and other lymphomas, leukaemias, mycosis fungoides (intravenous; discontinued)", "US 2013: Topical treatment of stage IA and IB mycosis fungoides-type CTCL after skin-directed therapy (Valchlor)", "EU 2017: Topical treatment of mycosis fungoides-type CTCL (Ledaga)" ;
  onco:cancers <https://onco.cc/cancers/hodgkin-lymphoma/>, <https://onco.cc/cancers/cutaneous-t-cell-lymphoma/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/> ;
  onco:companies <https://onco.cc/companies/helsinn/>, <https://onco.cc/companies/recordati/> ;
  onco:trials <https://onco.cc/trials/study-201/> .