# OnCo record mek (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/mek/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "mek" ;
  schema:name "MEK1/2"@en ;
  schema:description "MEK is the relay in the growth-signal chain that sits just below RAS and RAF. Blocking it starves BRAF- and RAS-driven tumours of their go signal."@en ;
  schema:url <https://onco.cc/targets/mek/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/MAP2K1> ;
  schema:citation <https://www.ncbi.nlm.nih.gov/gene/5604>, <https://www.ncbi.nlm.nih.gov/gene/5605> ;
  onco:tag "kinase" ;
  schema:alternateName "MAP2K1, MAP2K2" ;
  onco:targetClass "kinase" ;
  onco:cancers <https://onco.cc/cancers/melanoma/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/thyroid/>, <https://onco.cc/cancers/colorectal/> ;
  onco:drugs <https://onco.cc/drugs/mirdametinib/>, <https://onco.cc/drugs/atebimetinib/>, <https://onco.cc/drugs/gc101-til/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/>, <https://onco.cc/pathways/aml-signalling/>, <https://onco.cc/pathways/bladder-cancer-signalling/>, <https://onco.cc/pathways/breast-cancer-signalling/>, <https://onco.cc/pathways/cml-signalling/>, <https://onco.cc/pathways/melanoma-signalling/>, <https://onco.cc/pathways/nsclc-signalling/>, <https://onco.cc/pathways/thyroid-cancer-signalling/> .