# OnCo record melphalan (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/melphalan/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "melphalan" ;
  schema:name "Melphalan (including hepatic delivery system)"@en ;
  schema:description "The myeloma chemotherapy that is also the standard high-dose conditioning before autologous transplant, and, delivered directly into the liver's blood supply or the eye, treats uveal melanoma metastases and retinoblastoma."@en ;
  schema:url <https://onco.cc/drugs/melphalan/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Melphalan> ;
  owl:sameAs <http://www.wikidata.org/entity/Q2298283> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Hepzato>, <https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=melphalan> ;
  onco:status "approved" ;
  onco:tag "gap-fill", "generic" ;
  onco:modality "Alkylating agent (nitrogen mustard)" ;
  schema:alternateName "Alkeran / Evomela / Hepzato Kit" ;
  onco:approval "US 1964: Multiple myeloma; non-resectable epithelial ovarian carcinoma", "US 2016: High-dose conditioning before autologous HSCT in myeloma (Evomela)", "US 2023: Uveal melanoma with unresectable hepatic metastases via hepatic delivery system (Hepzato Kit)" ;
  onco:cancers <https://onco.cc/cancers/multiple-myeloma/>, <https://onco.cc/cancers/uveal-melanoma/>, <https://onco.cc/cancers/retinoblastoma/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/myeloma-transplant-eligible/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/autologous-stem-cell-transplant/>, <https://onco.cc/technologies/percutaneous-hepatic-perfusion/>, <https://onco.cc/technologies/isolated-limb-perfusion/> ;
  onco:trials <https://onco.cc/trials/nct05022901/>, <https://onco.cc/trials/nct06607458/> .