# OnCo record men2-syndrome (cancer). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/cancers/men2-syndrome/>
  a schema:MedicalCondition ;
  onco:kind "cancer" ;
  schema:identifier "men2-syndrome" ;
  schema:name "Multiple endocrine neoplasia type 2 (MEN2A and MEN2B)"@en ;
  schema:alternateName "MEN2"@en, "MEN2A"@en, "MEN2B"@en, "MEN3"@en, "Sipple syndrome"@en, "Familial medullary thyroid carcinoma (MEN2A variant)"@en, "MEN2A (RET; medullary thyroid carcinoma, pheochromocytoma, parathyroid)"@en, "MEN2B (RET M918T; early MTC, pheochromocytoma, mucosal neuromas)"@en ;
  schema:description "MEN2 is an inherited condition, one of the multiple endocrine neoplasia syndromes, in which a faulty RET gene causes medullary thyroid cancer in almost every carrier, often with adrenal tumours and overactive parathyroids. Because the thyroid cancer is so predictable, children who inherit the gene have the thyroid removed at an age set by which RET mutation they carry."@en ;
  schema:url <https://onco.cc/cancers/men2-syndrome/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Multiple_endocrine_neoplasia_type_2> ;
  schema:citation <https://www.cancer.gov/types/multiple-endocrine-neoplasia>, <https://doi.org/10.1089/thy.2014.0335>, <https://www.orpha.net/en/disease/detail/653>, <https://doi.org/10.3390/cancers16030494> ;
  onco:tag "subtype-page", "wave4", "rare" ;
  onco:related <https://onco.cc/cancers/multiple-endocrine-neoplasia/>, <https://onco.cc/cancers/men1-syndrome/>, <https://onco.cc/cancers/medullary-thyroid-cancer/>, <https://onco.cc/cancers/hereditary-ppgl/>, <https://onco.cc/cancers/pheochromocytoma-paraganglioma/> ;
  onco:technologies <https://onco.cc/technologies/germline-testing/> ;
  onco:targets <https://onco.cc/targets/ret/> ;
  onco:drugs <https://onco.cc/drugs/selpercatinib/>, <https://onco.cc/drugs/vandetanib/>, <https://onco.cc/drugs/cabozantinib/> ;
  onco:terms <https://onco.cc/terms/thyroidectomy/>, <https://onco.cc/terms/hereditary-cancer-syndromes/> ;
  onco:trials <https://onco.cc/trials/libretto-531/> ;
  onco:standardOfCare <https://onco.cc/terms/thyroidectomy/>, <https://onco.cc/targets/ret/>, <https://onco.cc/cancers/medullary-thyroid-cancer/>, <https://onco.cc/cancers/medullary-thyroid-cancer/>, <https://onco.cc/drugs/selpercatinib/>, <https://onco.cc/trials/libretto-531/> .