# OnCo record metabolic-theory-of-cancer (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/metabolic-theory-of-cancer/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "metabolic-theory-of-cancer" ;
  schema:name "Metabolic theory of cancer: from Warburg to oncometabolites"@en ;
  schema:alternateName "metabolic theory"@en, "Warburg hypothesis"@en, "cancer as a metabolic disease"@en, "mitochondrial theory of cancer"@en, "metabolic reprogramming"@en ;
  schema:description "Otto Warburg noticed a century ago that cancer cells ferment glucose even when oxygen is plentiful and concluded that damaged respiration causes cancer. The observation held and became the basis of PET scanning, but the causal claim did not: most cancers rewire metabolism because mutated signalling demands building blocks, and only a few metabolic enzymes are themselves cancer genes."@en ;
  schema:url <https://onco.cc/terms/metabolic-theory-of-cancer/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Warburg_effect_(oncology)> ;
  schema:citation <https://doi.org/10.1126/science.123.3191.309>, <https://doi.org/10.1126/science.1160809>, <https://doi.org/10.1186/1743-7075-7-7>, <https://doi.org/10.1016/j.cmet.2015.12.006> ;
  onco:tag "theory" ;
  onco:related <https://onco.cc/pathways/theories-of-cancer/>, <https://onco.cc/terms/warburg-effect/>, <https://onco.cc/terms/somatic-mutation-theory/>, <https://onco.cc/terms/hallmarks-synthesis/>, <https://onco.cc/terms/atavistic-theory-of-cancer/>, <https://onco.cc/terms/epigenetic-progenitor-theory/>, <https://onco.cc/pathways/cancer-metabolism/>, <https://onco.cc/pathways/glutamine-metabolism/>, <https://onco.cc/pathways/lipid-metabolism-cancer/>, <https://onco.cc/pathways/hif-vhl/>, <https://onco.cc/pathways/nutrient-competition-tme/>, <https://onco.cc/terms/deregulating-cellular-energetics/>, <https://onco.cc/technologies/fdg-pet/>, <https://onco.cc/technologies/idh-inhibitors/>, <https://onco.cc/technologies/metabolic-therapy/>, <https://onco.cc/technologies/ketogenic-diet-glioblastoma/>, <https://onco.cc/trials/ergo2/> ;
  onco:cancers <https://onco.cc/cancers/glioblastoma/>, <https://onco.cc/cancers/aml/> ;
  onco:technologies <https://onco.cc/technologies/fdg-pet/>, <https://onco.cc/technologies/idh-inhibitors/>, <https://onco.cc/technologies/metabolic-therapy/>, <https://onco.cc/technologies/ketogenic-diet-glioblastoma/> ;
  onco:targets <https://onco.cc/targets/idh/> ;
  onco:drugs <https://onco.cc/drugs/ivosidenib/>, <https://onco.cc/drugs/vorasidenib/> ;
  onco:pathways <https://onco.cc/pathways/cancer-metabolism/>, <https://onco.cc/pathways/glutamine-metabolism/>, <https://onco.cc/pathways/lipid-metabolism-cancer/>, <https://onco.cc/pathways/hif-vhl/>, <https://onco.cc/pathways/nutrient-competition-tme/> ;
  onco:trials <https://onco.cc/trials/ergo2/> ;
  onco:people <https://onco.cc/people/matthew-vander-heiden/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-pavlova-cell-metab/>, <https://onco.cc/key-papers/paper-vander-heiden-science/>, <https://onco.cc/key-papers/paper-warburg-science/>, <https://onco.cc/key-papers/paper-seyfried-nutr-metab-lond/> .