# OnCo record metaplasia-dysplasia-carcinoma-sequence (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/metaplasia-dysplasia-carcinoma-sequence/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "metaplasia-dysplasia-carcinoma-sequence" ;
  schema:name "Metaplasia, dysplasia, carcinoma in situ: the flat route to gallbladder cancer"@en ;
  schema:alternateName "dysplasia-carcinoma sequence"@en, "flat dysplasia of the gallbladder"@en, "BilIN of the gallbladder"@en, "biliary intraepithelial neoplasia"@en ;
  schema:description "Most gallbladder cancers grow out of flat, invisible changes in the lining: years of irritation from stones turn the mucosa metaplastic, then dysplastic, then into carcinoma in situ, and finally into invasive cancer, a process estimated at 10 to 15 years."@en ;
  schema:url <https://onco.cc/terms/metaplasia-dysplasia-carcinoma-sequence/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1002/jso.20527>, <https://doi.org/10.1053/gast.1996.v111.pm8698204>, <https://doi.org/10.1038/s41467-021-25012-9> ;
  onco:cancers <https://onco.cc/cancers/gallbladder/> ;
  onco:targets <https://onco.cc/targets/ctnnb1/>, <https://onco.cc/targets/tp53/> ;
  onco:terms <https://onco.cc/terms/dysplasia/>, <https://onco.cc/terms/intracholecystic-papillary-tubular-neoplasm/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-roa-gallbladder-preneoplastic-lesions-jso-2006/>, <https://onco.cc/key-papers/paper-roa-dysplasia-to-carcinoma-interval-gastroenterology-1996/>, <https://onco.cc/key-papers/paper-lin-gallbladder-neoplasia-carcinoma-evolution-nat-commun-2021/> .