# OnCo record metastatic-pdac (cancer). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/cancers/metastatic-pdac/>
  a schema:MedicalCondition ;
  onco:kind "cancer" ;
  schema:identifier "metastatic-pdac" ;
  schema:name "Metastatic pancreatic ductal adenocarcinoma"@en ;
  schema:alternateName "Metastatic pancreatic cancer"@en, "Stage IV pancreatic adenocarcinoma"@en, "Advanced pancreatic cancer"@en, "mPDAC"@en ;
  schema:description "Metastatic pancreatic cancer has spread beyond the pancreas, usually to the liver, and is treated with chemotherapy rather than surgery. Three combination regimens lengthen life, a minority of patients qualify for targeted drugs chosen by tumour or inherited mutations, and in 2026 the pan-RAS inhibitor daraxonrasib became the first drug against the KRAS mutation that drives almost every case."@en ;
  schema:url <https://onco.cc/cancers/metastatic-pdac/> ;
  schema:dateModified "2026-09-18"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Pancreatic_cancer> ;
  schema:citation <https://en.wikipedia.org/wiki/Pancreatic_cancer>, <https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1455> ;
  onco:tag "subtype-page", "gastrointestinal" ;
  onco:related <https://onco.cc/cancers/locally-advanced-pdac/>, <https://onco.cc/cancers/kras-g12c-pdac/>, <https://onco.cc/cancers/kras-wild-type-pdac/>, <https://onco.cc/cancers/brca-palb2-pdac/>, <https://onco.cc/cancers/msi-high-pdac/>, <https://onco.cc/cancers/resectable-pdac/>, <https://onco.cc/roadmaps/kras-roadmap/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/kras-inhibitors/>, <https://onco.cc/technologies/parp-inhibitor/>, <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/neoantigen-mrna-vaccine/>, <https://onco.cc/technologies/shared-antigen-vaccine/>, <https://onco.cc/technologies/car-t/>, <https://onco.cc/technologies/adc/>, <https://onco.cc/technologies/bispecific-antibody/>, <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/technologies/biliary-stenting-drainage/> ;
  onco:targets <https://onco.cc/targets/kras/>, <https://onco.cc/targets/brca/>, <https://onco.cc/targets/cldn18-2/>, <https://onco.cc/targets/mesothelin/>, <https://onco.cc/targets/her3/>, <https://onco.cc/targets/ntrk/>, <https://onco.cc/targets/pd1/>, <https://onco.cc/targets/fap/> ;
  onco:drugs <https://onco.cc/drugs/folfirinox/>, <https://onco.cc/drugs/nalirifox/>, <https://onco.cc/drugs/gemcitabine-nab-paclitaxel/>, <https://onco.cc/drugs/gemcitabine/>, <https://onco.cc/drugs/irinotecan/>, <https://onco.cc/drugs/fluorouracil/>, <https://onco.cc/drugs/olaparib/>, <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/zenocutuzumab/>, <https://onco.cc/drugs/daraxonrasib/>, <https://onco.cc/drugs/zoldonrasib/>, <https://onco.cc/drugs/mrtx1133/>, <https://onco.cc/drugs/eli-002-7p/>, <https://onco.cc/drugs/autogene-cevumeran/>, <https://onco.cc/drugs/ibi343/>, <https://onco.cc/drugs/cmg901/>, <https://onco.cc/drugs/satricabtagene-autoleucel/>, <https://onco.cc/drugs/fap-2286/>, <https://onco.cc/drugs/devimistat/>, <https://onco.cc/drugs/pamrevlumab/>, <https://onco.cc/drugs/eryaspase/>, <https://onco.cc/drugs/algenpantucel-l/> ;
  onco:companies <https://onco.cc/companies/ipsen/>, <https://onco.cc/companies/revolution-medicines/>, <https://onco.cc/companies/astrazeneca/>, <https://onco.cc/companies/merck/>, <https://onco.cc/companies/bms/>, <https://onco.cc/companies/biontech/>, <https://onco.cc/companies/elicio-therapeutics/>, <https://onco.cc/companies/innovent/>, <https://onco.cc/companies/astellas/>, <https://onco.cc/companies/carsgen/> ;
  onco:pathways <https://onco.cc/pathways/pancreatic-cancer-signalling/>, <https://onco.cc/pathways/ras-mapk/>, <https://onco.cc/pathways/immune-desert-exclusion/>, <https://onco.cc/pathways/cachexia-biology/> ;
  onco:terms <https://onco.cc/terms/kras-mutation-subtypes/>, <https://onco.cc/terms/ca19-9/>, <https://onco.cc/terms/metastasis/>, <https://onco.cc/terms/peritoneal-metastasis/>, <https://onco.cc/terms/gbrca-mutation/>, <https://onco.cc/terms/msi/>, <https://onco.cc/terms/gene-fusion/>, <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/cachexia/>, <https://onco.cc/terms/obstructive-jaundice/>, <https://onco.cc/terms/platinum-sensitivity/> ;
  onco:trials <https://onco.cc/trials/napoli-3/>, <https://onco.cc/trials/polo/>, <https://onco.cc/trials/rasolute-302/>, <https://onco.cc/trials/nct07491445/>, <https://onco.cc/trials/nct07805954/>, <https://onco.cc/trials/nct07621718/>, <https://onco.cc/trials/nct07522073/>, <https://onco.cc/trials/g-hope-002/>, <https://onco.cc/trials/nct04404595/>, <https://onco.cc/trials/nct06051695/>, <https://onco.cc/trials/nct07562152/>, <https://onco.cc/trials/nct06608927/>, <https://onco.cc/trials/mountaintap-30/>, <https://onco.cc/trials/precision-promise/>, <https://onco.cc/trials/avenger-500/>, <https://onco.cc/trials/lapis-trial/>, <https://onco.cc/trials/trybeca-1/>, <https://onco.cc/trials/impress-trial/>, <https://onco.cc/trials/notable-trial/> ;
  onco:people <https://onco.cc/people/daniel-von-hoff/>, <https://onco.cc/people/thierry-conroy/>, <https://onco.cc/people/zev-wainberg/>, <https://onco.cc/people/eileen-oreilly/>, <https://onco.cc/people/talia-golan/>, <https://onco.cc/people/tanios-bekaii-saab/>, <https://onco.cc/people/eric-van-cutsem/>, <https://onco.cc/people/volker-heinemann/>, <https://onco.cc/people/hedy-kindler/>, <https://onco.cc/people/kevan-shokat/>, <https://onco.cc/people/frank-mccormick/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-conroy-folfirinox-pancreatic-nejm-2011/>, <https://onco.cc/key-papers/paper-mpact-nab-paclitaxel-gemcitabine-nejm-2013/>, <https://onco.cc/key-papers/paper-napoli-3-lancet-2023/>, <https://onco.cc/key-papers/paper-burris-gemcitabine-pancreatic-jco-1997/>, <https://onco.cc/key-papers/paper-rahib-projecting-cancer-deaths-2030-cancerres-2014/> ;
  onco:pipeline <https://onco.cc/trials/nct07491445/>, <https://onco.cc/drugs/zoldonrasib/>, <https://onco.cc/trials/nct07805954/>, <https://onco.cc/trials/nct07621718/>, <https://onco.cc/trials/nct07522073/>, <https://onco.cc/drugs/mrtx1133/>, <https://onco.cc/drugs/eli-002-7p/>, <https://onco.cc/drugs/autogene-cevumeran/>, <https://onco.cc/trials/g-hope-002/>, <https://onco.cc/drugs/ibi343/>, <https://onco.cc/drugs/cmg901/>, <https://onco.cc/trials/nct04404595/>, <https://onco.cc/drugs/satricabtagene-autoleucel/>, <https://onco.cc/trials/nct06051695/>, <https://onco.cc/drugs/fap-2286/>, <https://onco.cc/trials/nct07562152/>, <https://onco.cc/trials/nct06608927/>, <https://onco.cc/trials/nct07259317/>, <https://onco.cc/trials/nct07450859/>, <https://onco.cc/trials/mountaintap-30/>, <https://onco.cc/drugs/elraglusib/>, <https://onco.cc/trials/precision-promise/>, <https://onco.cc/ideas/idea-bio1-pan-ras-covalent-g12d/>, <https://onco.cc/ideas/idea-shared-kras-vaccine-adjuvant/> ;
  onco:standardOfCare <https://onco.cc/drugs/folfirinox/>, <https://onco.cc/drugs/nalirifox/>, <https://onco.cc/trials/napoli-3/>, <https://onco.cc/drugs/gemcitabine-nab-paclitaxel/>, <https://onco.cc/drugs/gemcitabine-nab-paclitaxel/>, <https://onco.cc/drugs/gemcitabine/>, <https://onco.cc/terms/cachexia/>, <https://onco.cc/drugs/olaparib/>, <https://onco.cc/trials/polo/>, <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/zenocutuzumab/>, <https://onco.cc/drugs/larotrectinib/>, <https://onco.cc/drugs/dabrafenib-trametinib/>, <https://onco.cc/drugs/daraxonrasib/>, <https://onco.cc/trials/rasolute-302/>, <https://onco.cc/drugs/irinotecan/>, <https://onco.cc/drugs/fluorouracil/>, <https://onco.cc/drugs/gemcitabine-nab-paclitaxel/>, <https://onco.cc/technologies/biliary-stenting-drainage/>, <https://onco.cc/terms/cachexia/>, <https://onco.cc/terms/obstructive-jaundice/>, <https://onco.cc/trials/nct07491445/>, <https://onco.cc/drugs/zoldonrasib/>, <https://onco.cc/trials/nct07805954/>, <https://onco.cc/drugs/eli-002-7p/>, <https://onco.cc/trials/g-hope-002/>, <https://onco.cc/trials/nct04404595/>, <https://onco.cc/trials/precision-promise/> .
