# OnCo record methotrexate (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/methotrexate/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "methotrexate" ;
  schema:name "Methotrexate"@en ;
  schema:description "The 1948 antifolate that produced the first chemotherapy remissions in childhood leukaemia and the first cure of a solid tumour; still essential in ALL, lymphoma, osteosarcoma and CNS lymphoma."@en ;
  schema:url <https://onco.cc/drugs/methotrexate/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Methotrexate> ;
  owl:sameAs <http://www.wikidata.org/entity/Q422232> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=methotrexate%20injection> ;
  onco:status "approved" ;
  onco:tag "gap-fill", "generic", "who-essential" ;
  onco:modality "Antifolate (DHFR inhibitor)" ;
  schema:alternateName "Trexall / Otrexup / Xatmep" ;
  onco:approval "US 1953: ALL, choriocarcinoma, and later osteosarcoma, breast, head and neck, lung, lymphoma, mycosis fungoides" ;
  onco:related <https://onco.cc/drugs/glucarpidase/> ;
  onco:cancers <https://onco.cc/cancers/all-leukemia/>, <https://onco.cc/cancers/osteosarcoma/>, <https://onco.cc/cancers/primary-cns-lymphoma/>, <https://onco.cc/cancers/gestational-trophoblastic/>, <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/urothelial/>, <https://onco.cc/cancers/head-and-neck/>, <https://onco.cc/cancers/low-risk-gtn/>, <https://onco.cc/cancers/high-risk-gtn/>, <https://onco.cc/cancers/placental-site-trophoblastic-tumour/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/> ;
  onco:terms <https://onco.cc/terms/blood-brain-barrier/> ;
  onco:trials <https://onco.cc/trials/euramos-1/>, <https://onco.cc/trials/dbcg-82bc/>, <https://onco.cc/trials/nct05663866/>, <https://onco.cc/trials/nct06960577/>, <https://onco.cc/trials/nct07015242/>, <https://onco.cc/trials/nct07387926/> .