# OnCo record methylnaltrexone (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/methylnaltrexone/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "methylnaltrexone" ;
  schema:name "Methylnaltrexone"@en ;
  schema:description "Methylnaltrexone (Relistor) is an injection or tablet that relieves the severe constipation caused by strong painkillers in people with advanced cancer, without blocking the pain relief itself."@en ;
  schema:url <https://onco.cc/drugs/methylnaltrexone/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Methylnaltrexone> ;
  schema:citation <https://doi.org/10.1056/NEJMoa0707377>, <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c488fb7c-0a5b-487c-b452-996809d1cb99>, <https://www.cancer.gov/about-cancer/treatment/drugs/methylnaltrexonebromide>, <https://www.ema.europa.eu/en/medicines/human/EPAR/relistor> ;
  onco:status "approved" ;
  onco:tag "nci-list", "supportive" ;
  onco:modality "Peripherally acting mu-opioid receptor antagonist" ;
  schema:alternateName "Relistor" ;
  onco:approval "US 2008: Opioid-induced constipation in advanced illness receiving palliative care (chronic non-cancer pain and oral tablets added 2014 to 2016)", "EU 2008: Opioid-induced constipation in advanced illness receiving palliative care when laxatives are insufficient (Relistor)" ;
  onco:technologies <https://onco.cc/technologies/palliative-care/>, <https://onco.cc/technologies/pain-management/> ;
  onco:targets <https://onco.cc/targets/oprm1/> ;
  onco:companies <https://onco.cc/companies/bausch-health/> ;
  onco:trials <https://onco.cc/trials/mntx-302/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-mntx-302-thomas-nejm-2008/> .