# OnCo record mgmt-promoter-methylation (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/mgmt-promoter-methylation/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "mgmt-promoter-methylation" ;
  schema:name "MGMT promoter methylation"@en ;
  schema:alternateName "MGMT methylation"@en, "MGMT methylated"@en, "MGMT promoter methylated"@en, "MGMT unmethylated"@en, "methylated MGMT"@en, "MGMT status"@en ;
  schema:description "Methylation of the MGMT promoter switches off the repair enzyme that undoes temozolomide's damage. Methylated glioblastomas live longer on temozolomide; unmethylated ones gain little, and trials now use the result to spare or intensify chemotherapy."@en ;
  schema:url <https://onco.cc/biomarkers/mgmt-promoter-methylation/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa043331>, <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=046a9011-3911-4d3f-a15f-fbb56d5aad56> ;
  onco:tag "biomarker", "methylation", "no-approval" ;
  onco:related <https://onco.cc/biomarkers/idh1-r132/>, <https://onco.cc/biomarkers/1p19q-codeletion-readout/>, <https://onco.cc/biomarkers/h3-k27m/> ;
  onco:cancers <https://onco.cc/cancers/glioblastoma/>, <https://onco.cc/cancers/idh-mutant-astrocytoma/> ;
  onco:drugs <https://onco.cc/drugs/temozolomide/> ;
  onco:terms <https://onco.cc/terms/mgmt/>, <https://onco.cc/terms/alkylating-agent/> .