# OnCo record mgmt-protein (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/mgmt-protein/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "mgmt-protein" ;
  schema:name "MGMT (O6-methylguanine-DNA methyltransferase)"@en ;
  schema:alternateName "O-6-methylguanine-DNA methyltransferase"@en, "AGT"@en, "O6-alkylguanine DNA alkyltransferase"@en, "MGMT" ;
  schema:description "MGMT is a DNA repair enzyme that removes the damage temozolomide causes; when the gene is switched off by methylation the tumour cannot repair itself and the drug works better."@en ;
  schema:url <https://onco.cc/targets/mgmt-protein/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/O-6-methylguanine-DNA_methyltransferase>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7059>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000170430>, <https://www.uniprot.org/uniprotkb/P16455/entry>, <https://www.ncbi.nlm.nih.gov/gene/4255> ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7059>, <https://www.uniprot.org/uniprotkb/P16455/entry> ;
  onco:tag "biomarker-parent" ;
  onco:targetClass "enzyme" ;
  onco:related <https://onco.cc/biomarkers/mgmt-promoter-methylation/> ;
  onco:cancers <https://onco.cc/cancers/glioblastoma/> ;
  onco:drugs <https://onco.cc/drugs/temozolomide/> ;
  onco:terms <https://onco.cc/terms/mgmt/> .