# OnCo record microenvironment-inflammation-theory (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/microenvironment-inflammation-theory/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "microenvironment-inflammation-theory" ;
  schema:name "Microenvironment and inflammation: tumours as wounds that do not heal"@en ;
  schema:alternateName "microenvironment theory"@en, "inflammation theory of cancer"@en, "wounds that do not heal"@en, "tumour as an overhealing wound"@en, "Virchow hypothesis"@en, "stromal theory of cancer"@en ;
  schema:description "A tumour is not a lump of cancer cells but a tissue: fibroblasts, vessels and immune cells, recruited by the signals a wound uses and never told to stop. Virchow saw white cells in tumours in 1863; Dvorak called tumours 'wounds that do not heal' in 1986. It explains why chronic inflammation causes about a fifth of cancers and why aspirin, HPV and hepatitis vaccines and anti-angiogenic drugs work."@en ;
  schema:url <https://onco.cc/terms/microenvironment-inflammation-theory/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Tumor_microenvironment> ;
  schema:citation <https://doi.org/10.1056/NEJM198612253152606>, <https://doi.org/10.1016/S0140-6736(00)04046-0>, <https://doi.org/10.1038/nature01322>, <https://doi.org/10.1016/j.ccr.2012.02.022>, <https://doi.org/10.1038/nrm2455>, <https://doi.org/10.1016/S0140-6736(10)62110-1>, <https://doi.org/10.1016/S0140-6736(17)32247-X>, <https://doi.org/10.1200/JCO.20.00590> ;
  onco:tag "theory" ;
  onco:related <https://onco.cc/pathways/theories-of-cancer/>, <https://onco.cc/terms/inflammation/>, <https://onco.cc/pathways/tumor-microenvironment/>, <https://onco.cc/terms/tissue-organisation-field-theory/>, <https://onco.cc/terms/seed-and-soil-hypothesis/>, <https://onco.cc/terms/immune-surveillance-immunoediting/>, <https://onco.cc/terms/hallmarks-synthesis/>, <https://onco.cc/terms/mechanical-theory-of-cancer/>, <https://onco.cc/terms/ageing-tissue-field-theory/>, <https://onco.cc/pathways/inflammation-nfkb/>, <https://onco.cc/terms/tumor-promoting-inflammation/>, <https://onco.cc/terms/cancer-associated-fibroblasts/>, <https://onco.cc/pathways/caf-activation-desmoplasia/>, <https://onco.cc/pathways/angiogenic-switch/>, <https://onco.cc/pathways/vegf-angiogenesis/>, <https://onco.cc/pathways/oncogenic-viruses/>, <https://onco.cc/technologies/aspirin-cancer-prevention/>, <https://onco.cc/technologies/hpv-vaccine/>, <https://onco.cc/terms/macrophage/>, <https://onco.cc/terms/cold-vs-hot/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/hcc/>, <https://onco.cc/cancers/cervical/> ;
  onco:technologies <https://onco.cc/technologies/aspirin-cancer-prevention/>, <https://onco.cc/technologies/hpv-vaccine/>, <https://onco.cc/technologies/chemoprevention/> ;
  onco:targets <https://onco.cc/targets/vegf/>, <https://onco.cc/targets/il6/>, <https://onco.cc/targets/fap/> ;
  onco:drugs <https://onco.cc/drugs/bevacizumab/>, <https://onco.cc/drugs/aspirin/> ;
  onco:pathways <https://onco.cc/pathways/tumor-microenvironment/>, <https://onco.cc/pathways/inflammation-nfkb/>, <https://onco.cc/pathways/caf-activation-desmoplasia/>, <https://onco.cc/pathways/angiogenic-switch/>, <https://onco.cc/pathways/vegf-angiogenesis/>, <https://onco.cc/pathways/oncogenic-viruses/>, <https://onco.cc/pathways/myeloid-suppression-axis/> ;
  onco:trials <https://onco.cc/trials/add-aspirin/> ;
  onco:people <https://onco.cc/people/johanna-joyce/>, <https://onco.cc/people/judah-folkman/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-balkwill-mantovani-inflammation-virchow-lancet-2001/>, <https://onco.cc/key-papers/paper-coussens-werb-inflammation-cancer-nature-2002/>, <https://onco.cc/key-papers/paper-quail-joyce-microenvironment-metastasis-natmed-2013/>, <https://onco.cc/key-papers/paper-halo-301-pegvorhyaluronidase-jco-2020/>, <https://onco.cc/key-papers/paper-hanahan-cancer-cell/>, <https://onco.cc/key-papers/paper-rothwell-lancet/>, <https://onco.cc/key-papers/paper-ridker-lancet/>, <https://onco.cc/key-papers/paper-schafer-nat-rev-mol-cell-biol/>, <https://onco.cc/key-papers/paper-dvorak-n-engl-j-med/> .