# OnCo record mitotic-spindle-checkpoint (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/mitotic-spindle-checkpoint/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "mitotic-spindle-checkpoint" ;
  schema:name "Mitosis & the spindle assembly checkpoint"@en ;
  schema:description "When a cell divides, a scaffold of microtubules (the spindle) pulls one copy of each chromosome to each side. A checkpoint holds the split until every chromosome is hooked on. Taxanes and vinca alkaloids freeze the spindle so the cell is stuck at this checkpoint until it dies."@en ;
  schema:url <https://onco.cc/pathways/mitotic-spindle-checkpoint/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Spindle_checkpoint> ;
  schema:citation <https://doi.org/10.1038/nrm2163> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/adc/> ;
  onco:targets <https://onco.cc/targets/her2/>, <https://onco.cc/targets/nectin4/>, <https://onco.cc/targets/cd30/>, <https://onco.cc/targets/folr1/>, <https://onco.cc/targets/bcl2/>, <https://onco.cc/targets/tp53/> ;
  onco:drugs <https://onco.cc/drugs/paclitaxel/>, <https://onco.cc/drugs/docetaxel/>, <https://onco.cc/drugs/cabazitaxel/>, <https://onco.cc/drugs/eribulin/>, <https://onco.cc/drugs/vincristine/>, <https://onco.cc/drugs/vinblastine/>, <https://onco.cc/drugs/vinorelbine/>, <https://onco.cc/drugs/trastuzumab-emtansine/>, <https://onco.cc/drugs/enfortumab-vedotin/>, <https://onco.cc/drugs/brentuximab-vedotin/>, <https://onco.cc/drugs/mirvetuximab-soravtansine/> ;
  onco:pathways <https://onco.cc/pathways/chromosomal-instability/>, <https://onco.cc/pathways/cell-cycle-engine-cdks/>, <https://onco.cc/pathways/p53-cell-cycle/>, <https://onco.cc/pathways/apoptosis-bcl2/> ;
  onco:terms <https://onco.cc/terms/tubulin-inhibitor-payloads/>, <https://onco.cc/terms/mmae/>, <https://onco.cc/terms/dm1/>, <https://onco.cc/terms/dm4/>, <https://onco.cc/terms/whole-genome-doubling/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-musacchio-nat-rev-mol-cell-biol/> .