# OnCo record mlh1-promoter-methylation (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/mlh1-promoter-methylation/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "mlh1-promoter-methylation" ;
  schema:name "MLH1 promoter methylation (sporadic versus Lynch mismatch repair loss)"@en ;
  schema:alternateName "MLH1 promoter hypermethylation"@en, "MLH1 hypermethylation"@en, "MLH1 methylation"@en, "sporadic MSI-high"@en, "sporadic dMMR"@en, "epigenetic MLH1 silencing"@en, "MLH1 silencing"@en, "BRAF V600E reflex testing"@en, "reflex testing for Lynch syndrome"@en ;
  schema:description "When a tumour has lost the MLH1 mismatch-repair protein, a methylation test on the tumour tells the two causes apart: methylation switching the gene off means a sporadic cancer, no methylation means an inherited Lynch syndrome mutation is likely and the whole family needs testing."@en ;
  schema:url <https://onco.cc/terms/mlh1-promoter-methylation/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  onco:related <https://onco.cc/terms/msi/>, <https://onco.cc/terms/lynch-syndrome/>, <https://onco.cc/terms/braf-v600-mutation/>, <https://onco.cc/technologies/germline-testing/>, <https://onco.cc/technologies/msi-mmr-testing/>, <https://onco.cc/terms/hereditary-cancer-syndromes/>, <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/terms/ihc/> ;
  onco:cancers <https://onco.cc/cancers/msi-high-colorectal/>, <https://onco.cc/cancers/endometrial-mmr-deficient/>, <https://onco.cc/cancers/gastric-msi-high/> .