# OnCo record mntx-302 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/mntx-302/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "mntx-302", "NCT00402038" ;
  schema:name "MNTX 302"@en ;
  schema:alternateName "Study 5"@en, "MNTX302"@en ;
  schema:description "MNTX 302 showed that a gut-only opioid blocker injected under the skin produced a bowel movement within four hours in about half of people with advanced illness on strong painkillers, against about one in seven on placebo, without weakening pain relief; it was one of the two trials behind the US approval of Relistor."@en ;
  schema:url <https://onco.cc/trials/mntx-302/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT00402038>, <https://doi.org/10.1056/NEJMoa0707377>, <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c488fb7c-0a5b-487c-b452-996809d1cb99> ;
  onco:status "positive" ;
  onco:phase "3" ;
  onco:sections <https://onco.cc/fronts/supportive-care/> ;
  onco:drugs <https://onco.cc/drugs/methylnaltrexone/> ;
  onco:companies <https://onco.cc/companies/bausch-health/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-mntx-302-thomas-nejm-2008/> .