# OnCo record motion (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/motion/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "motion", "NCT05059262" ;
  schema:name "MOTION"@en ;
  schema:description "MOTION randomised 123 patients with symptomatic tenosynovial giant cell tumour not suitable for surgery to the CSF1R inhibitor vimseltinib or placebo. Tumours shrank in 40% on vimseltinib versus none on placebo, with better joint movement, pain and function, leading to approval in February 2025; whether responses last after stopping is unknown."@en ;
  schema:url <https://onco.cc/trials/motion/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT05059262> ;
  onco:status "positive" ;
  onco:phase "3" ;
  schema:startDate "2021-10-14" ;
  onco:cancers <https://onco.cc/cancers/sarcoma/>, <https://onco.cc/cancers/tenosynovial-giant-cell-tumour/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:drugs <https://onco.cc/drugs/vimseltinib/> ;
  onco:companies <https://onco.cc/companies/deciphera/> .