# OnCo record mountaineer (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/mountaineer/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "mountaineer", "NCT03043313" ;
  schema:name "MOUNTAINEER"@en ;
  schema:description "A HER2 pill plus antibody gave durable responses in the 3-5% of bowel cancers driven by HER2, and is now being tested as first-line treatment."@en ;
  schema:url <https://onco.cc/trials/mountaineer/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT03043313>, <https://clinicaltrials.gov/study/NCT05253651>, <https://doi.org/10.1016/S1470-2045(23)00150-X> ;
  onco:status "completed" ;
  onco:phase "2" ;
  schema:startDate "2017-06-23" ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/her2-amplified-colorectal/> ;
  onco:technologies <https://onco.cc/technologies/her2-tyrosine-kinase-inhibitors/>, <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/her2/> ;
  onco:drugs <https://onco.cc/drugs/tucatinib/>, <https://onco.cc/drugs/trastuzumab/>, <https://onco.cc/drugs/folfox/>, <https://onco.cc/drugs/bevacizumab/>, <https://onco.cc/drugs/cetuximab/>, <https://onco.cc/drugs/oxaliplatin/> ;
  onco:companies <https://onco.cc/companies/pfizer/> ;
  onco:trials <https://onco.cc/trials/mountaineer-03/>, <https://onco.cc/trials/destiny-crc01/> ;
  onco:people <https://onco.cc/people/tanios-bekaii-saab/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-valtorta-her2-scoring-colorectal-heracles-mod-pathol-2015/>, <https://onco.cc/key-papers/paper-richman-her2-amplification-quasar-focus-piccolo-j-pathol-2016/>, <https://onco.cc/key-papers/paper-strickler-mountaineer-tucatinib-trastuzumab-lancet-oncol-2023/>, <https://onco.cc/key-papers/paper-mountaineer-nat-commun-2026-update/> .