# OnCo record mpl (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/mpl/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "mpl" ;
  schema:name "MPL (thrombopoietin receptor)"@en ;
  schema:alternateName "TPO receptor"@en, "TPOR"@en, "THPOR"@en, "CD110"@en, "MPL proto-oncogene, thrombopoietin receptor"@en, "MPL" ;
  schema:description "MPL is the receptor that tells the bone marrow to make platelets. Romiplostim and eltrombopag switch it on to raise platelet counts; in some myeloproliferative neoplasms a mutant partner protein, calreticulin, grips it and keeps it on."@en ;
  schema:url <https://onco.cc/targets/mpl/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7217>, <https://www.uniprot.org/uniprotkb/P40238/entry>, <https://www.ncbi.nlm.nih.gov/gene/4352> ;
  onco:tag "wave5-target" ;
  onco:targetClass "surface-antigen" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7217>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000117400>, <https://www.uniprot.org/uniprotkb/P40238/entry>, <https://www.ncbi.nlm.nih.gov/gene/4352> ;
  onco:related <https://onco.cc/drugs/inca033989/>, <https://onco.cc/drugs/ruxolitinib/>, <https://onco.cc/targets/jak2/> ;
  onco:cancers <https://onco.cc/cancers/myeloproliferative-neoplasms/>, <https://onco.cc/cancers/essential-thrombocythaemia/>, <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/mds/> ;
  onco:technologies <https://onco.cc/technologies/transfusion-support/> ;
  onco:drugs <https://onco.cc/drugs/romiplostim/>, <https://onco.cc/drugs/eltrombopag/> ;
  onco:pathways <https://onco.cc/pathways/jak-stat/> .