# OnCo record mrna-translation-eif4f (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/mrna-translation-eif4f/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "mrna-translation-eif4f" ;
  schema:name "mRNA translation (eIF4F / mTOR)"@en ;
  schema:description "Cancer cells must make protein at furious speed. The eIF4F complex that starts protein synthesis is the funnel where growth signals converge, and drugs that pinch the funnel starve the tumour of the proteins it needs most."@en ;
  schema:url <https://onco.cc/pathways/mrna-translation-eif4f/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/EIF4E> ;
  owl:sameAs <http://www.wikidata.org/entity/Q5408696> ;
  schema:citation <https://doi.org/10.1038/s41568-021-00380-y> ;
  onco:tag "mechanism" ;
  onco:targets <https://onco.cc/targets/akt/>, <https://onco.cc/targets/pik3ca/> ;
  onco:drugs <https://onco.cc/drugs/everolimus/> ;
  onco:institutions <https://onco.cc/institutions/mgh/>, <https://onco.cc/institutions/mskcc/>, <https://onco.cc/institutions/ucsf/> ;
  onco:pathways <https://onco.cc/pathways/pi3k-akt-mtor/>, <https://onco.cc/pathways/myc/>, <https://onco.cc/pathways/ras-mapk/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-fabbri-nat-rev-cancer/> .