# OnCo record msi-high (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/msi-high/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "msi-high" ;
  schema:name "MSI-high (microsatellite instability by PCR or sequencing)"@en ;
  schema:alternateName "MSI-H"@en, "MSI-high"@en, "MSI high"@en, "microsatellite instability-high"@en, "microsatellite unstable"@en, "MSI status"@en, "MSI-H/dMMR"@en, "MSS"@en, "microsatellite stable"@en ;
  schema:description "MSI-high means the tumour's DNA has unstable repeat sequences, the footprint of failed mismatch repair. It is measured by PCR or sequencing, gives the same answer as dMMR in most tumours, and unlocks the same immunotherapies."@en ;
  schema:url <https://onco.cc/biomarkers/msi-high/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9333c79b-d487-4538-a9f0-71b91a02b287>, <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f570b9c4-6846-4de2-abfa-4d0a4ae4e394> ;
  onco:tag "biomarker", "mmr" ;
  onco:related <https://onco.cc/biomarkers/dmmr-ihc/>, <https://onco.cc/biomarkers/tmb-high/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/endometrial/>, <https://onco.cc/cancers/endometrial-mmr-deficient/>, <https://onco.cc/cancers/gastric-msi-high/>, <https://onco.cc/cancers/metastatic-cancer/> ;
  onco:drugs <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/nivolumab/>, <https://onco.cc/drugs/ipilimumab/>, <https://onco.cc/drugs/dostarlimab/>, <https://onco.cc/drugs/lenvatinib/>, <https://onco.cc/drugs/foundationone-cdx/>, <https://onco.cc/drugs/caris-mi-cancer-seek/> ;
  onco:terms <https://onco.cc/terms/msi/>, <https://onco.cc/terms/mss-pmmr/>, <https://onco.cc/terms/ngs/>, <https://onco.cc/terms/tumour-agnostic/> .