# OnCo record msi-mmr-testing (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/msi-mmr-testing/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "msi-mmr-testing" ;
  schema:name "MSI and mismatch-repair testing"@en ;
  schema:description "Tests that show whether a tumour has lost its DNA spell-checker; if so, immunotherapy works unusually well and an inherited syndrome may be present."@en ;
  schema:url <https://onco.cc/technologies/msi-mmr-testing/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Microsatellite_instability> ;
  schema:citation <https://web.archive.org/web/20260420012135/https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-pembrolizumab-first-tissuesite-agnostic-indication>, <https://www.macmillan.org.uk/cancer-information-and-support/bowel-cancer/tests-on-the-bowel-cancer-cells>, <https://www.nice.org.uk/guidance/ng151/chapter/Recommendations>, <https://www.bowelcanceruk.org.uk/campaigning/never-too-young/lynch-syndrome/> ;
  onco:status "standard-of-care" ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/endometrial/>, <https://onco.cc/cancers/gastric/> ;
  onco:sections <https://onco.cc/fronts/diagnostics/> ;
  onco:technologies <https://onco.cc/technologies/histopathology-ihc/>, <https://onco.cc/technologies/companion-diagnostic/>, <https://onco.cc/technologies/germline-testing/> ;
  onco:drugs <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/dostarlimab/>, <https://onco.cc/drugs/ventana-mmr-rxdx/>, <https://onco.cc/drugs/foundationone-cdx/> ;
  onco:terms <https://onco.cc/terms/msi/>, <https://onco.cc/terms/mss-pmmr/>, <https://onco.cc/terms/lynch-syndrome/>, <https://onco.cc/terms/tmb/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-moreira-lynch-syndrome-identification-jama-2012/>, <https://onco.cc/key-papers/paper-herman-mlh1-promoter-hypermethylation-colorectal-pnas-1998/>, <https://onco.cc/key-papers/paper-weisenberger-cimp-braf-mlh1-colorectal-nat-genet-2006/>, <https://onco.cc/key-papers/paper-sepulveda-molecular-biomarkers-colorectal-guideline-jco-2017/> .