# OnCo record msi (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/msi/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "msi" ;
  schema:name "Microsatellite instability (MSI-H) / mismatch repair deficiency (dMMR)"@en ;
  schema:alternateName "MSI-high"@en, "microsatellite instability-high"@en, "mismatch repair-deficient"@en, "mismatch repair deficient"@en, "MMR-deficient"@en, "MMR deficiency"@en, "MMRd"@en, "MMR immunohistochemistry"@en, "mismatch repair immunohistochemistry"@en, "MMR IHC"@en, "mismatch repair proteins"@en, "MLH1, MSH2, MSH6 and PMS2"@en, "MSI by PCR"@en, "microsatellite instability testing"@en, "MSI testing"@en ;
  schema:description "Microsatellite instability is the mark of a broken DNA spell-checker (loss of MLH1, MSH2, MSH6 or PMS2) that leaves thousands of mutations, so the tumour displays abnormal proteins that T cells can recognise. It is found in a fraction of colorectal and endometrial cancers and was the basis of the first tumour-agnostic approval, pembrolizumab in 2017."@en ;
  schema:url <https://onco.cc/terms/msi/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Microsatellite_instability> ;
  owl:sameAs <http://www.wikidata.org/entity/Q488212> ;
  schema:citation <https://en.wikipedia.org/wiki/Microsatellite_instability> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/endometrial/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mcrpc/> ;
  onco:drugs <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/dostarlimab/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-le-mmr-deficiency-pd1-nejm-2015/>, <https://onco.cc/key-papers/paper-venderbosch-mmr-braf-metastatic-colorectal-pooled-ccr-2014/>, <https://onco.cc/key-papers/paper-koopman-deficient-mismatch-repair-advanced-colorectal-bjc-2009/>, <https://onco.cc/key-papers/paper-markowitz-tgfbr2-inactivation-msi-colon-science-1995/>, <https://onco.cc/key-papers/paper-abida-msi-prostate-checkpoint-blockade-jama-oncol-2019/>, <https://onco.cc/key-papers/paper-pritchard-complex-msh2-msh6-hypermutated-prostate-nat-commun-2014/>, <https://onco.cc/key-papers/paper-guedes-msh2-loss-primary-prostate-ccr-2017/> .