# OnCo record mtd (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/mtd/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "mtd" ;
  schema:name "Maximum tolerated dose (MTD)"@en ;
  schema:alternateName "MTD"@en, "maximum tolerated dose"@en, "maximally tolerated dose"@en, "MTD not reached"@en, "MTD was not reached"@en, "below the MTD"@en, "dose optimisation"@en, "dose optimization"@en, "optimal dose"@en, "optimal biological dose"@en, "OBD"@en, "randomised dose comparison"@en, "dose-response"@en ;
  schema:description "The highest dose of a drug at which about a third of patients or fewer have dose-limiting side effects, the traditional target of phase 1 trials. For chemotherapy more was better; targeted drugs and antibodies often saturate their target far below it, which is why the FDA's Project Optimus now asks for two doses to be compared."@en ;
  schema:url <https://onco.cc/terms/mtd/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Maximum_tolerated_dose> ;
  schema:citation <https://en.wikipedia.org/wiki/Maximum_tolerated_dose> ;
  onco:related <https://onco.cc/terms/dose-limiting-toxicity/>, <https://onco.cc/terms/rp2d/>, <https://onco.cc/terms/dose-escalation-design/>, <https://onco.cc/terms/therapeutic-index/>, <https://onco.cc/terms/pharmacokinetics/> ;
  onco:sections <https://onco.cc/fronts/drug-discovery/> ;
  onco:technologies <https://onco.cc/terms/project-optimus/> .