# OnCo record mutagenesis-signatures (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/mutagenesis-signatures/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "mutagenesis-signatures" ;
  schema:name "Mutagenesis & mutational signatures"@en ;
  schema:description "Every cause of DNA damage leaves its own fingerprint in the genome: sunlight, tobacco, a faulty repair enzyme, a gut bacterium. Reading these fingerprints tells you what caused a cancer and which repair crews it is missing, which in turn predicts which drugs will work."@en ;
  schema:url <https://onco.cc/pathways/mutagenesis-signatures/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Mutational_signatures> ;
  schema:citation <https://doi.org/10.1038/s41586-020-1943-3>, <https://cancer.sanger.ac.uk/signatures/> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:cancers <https://onco.cc/cancers/tnbc/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/technologies/hrd-testing/>, <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/smoking-cessation-after-diagnosis/>, <https://onco.cc/technologies/hpv-vaccine/> ;
  onco:targets <https://onco.cc/targets/brca/>, <https://onco.cc/targets/parp/>, <https://onco.cc/targets/pd1/> ;
  onco:drugs <https://onco.cc/drugs/olaparib/>, <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/dostarlimab/>, <https://onco.cc/drugs/temozolomide/> ;
  onco:pathways <https://onco.cc/pathways/ddr/>, <https://onco.cc/pathways/mismatch-repair-msi/>, <https://onco.cc/pathways/homologous-recombination-repair/>, <https://onco.cc/pathways/clonal-evolution/> ;
  onco:terms <https://onco.cc/terms/mutational-signature/>, <https://onco.cc/terms/tmb/>, <https://onco.cc/terms/msi/>, <https://onco.cc/terms/hrd/>, <https://onco.cc/terms/mgmt/>, <https://onco.cc/terms/neoantigen/>, <https://onco.cc/terms/genome-instability-mutation/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-alexandrov-nature/> .